Explain the pathophysiology of the disorders depicted in the scenarios
Application: Adaptive Response
As an advanced practice nurse, you will examine patients presenting with a variety of disorders. You must, therefore, understand how the body normally functions so that you can identify when it is reacting to changes. Often, when changes occur in body systems, the body reacts with compensatory mechanisms. These compensatory mechanisms, such as adaptive responses, might be signs and symptoms of alterations or underlying disorders. In the clinical setting, you use these responses, along with other patient factors, to lead you to a diagnosis.
Consider the following scenarios:
Scenario 1:
Jennifer is a 2-year-old female who presents with her mother. Mom is concerned because Jennifer has been “running a temperature” for the last 3 days. Mom says that Jennifer is usually healthy and has no significant medical history. She was in her usual state of good health until 3 days ago when she started to get fussy, would not eat her breakfast, and would not sit still for her favorite television cartoon. Since then she has had a fever off and on, anywhere between 101oF and today’s high of 103.2oF. Mom has been giving her ibuprofen, but when the fever went up to 103.2oF today, she felt that she should come in for evaluation. A physical examination reveals a height and weight appropriate 2-year-old female who appears acutely unwell. Her skin is hot and dry. The tympanic membranes are slightly reddened on the periphery, but otherwise normal in appearance. The throat is erythematous with 4+ tonsils and diffuse exudates. Anterior cervical nodes are readily palpable and clearly tender to touch on the left side. The child indicates that her throat hurts “a lot” and it is painful to swallow. Vital signs reveal a temperature of 102.8oF, a pulse of 128 beats per minute, and a respiratory rate of 24 beats per minute.
Scenario 2:
Jack is a 27-year-old male who presents with redness and irritation of his hands. He reports that he has never had a problem like this before, but about 2 weeks ago he noticed that both his hands seemed to be really red and flaky. He denies any discomfort, stating that sometimes they feel “a little bit hot,” but otherwise they feel fine. He does not understand why they are so red. His wife told him that he might have an allergy and he should get some steroid cream. Jack has no known allergies and no significant medical history except for recurrent ear infections as a child. He denies any traumatic injury or known exposure to irritants. He is a maintenance engineer in a newspaper building and admits that he often works with abrasive solvents and chemicals. Normally he wears protective gloves, but lately they seem to be in short supply so sometimes he does not use them. He has exposed his hands to some of these cleaning fluids, but says that it never hurt and he always washed his hands when he was finished.
Scenario 3:
Martha is a 65-year-old woman who recently retired from her job as an administrative assistant at a local hospital. Her medical history is significant for hypertension, which has been controlled for years with hydrochlorothiazide. She reports that lately she is having a lot of trouble sleeping, she occasionally feels like she has a “racing heartbeat,” and she is losing her appetite. She emphasizes that she is not hungry like she used to be. The only significant change that has occurred lately in her life is that her 87-year-old mother moved into her home a few years ago. Mom had always been healthy, but she fell down a flight of stairs and broke her hip. Her recovery was a difficult one, as she has lost a lot of mobility and independence and needs to rely on her daughter for assistance with activities of daily living. Martha says it is not the retirement she dreamed about, but she is an only child and is happy to care for her mother. Mom wakes up early in the morning, likes to bathe every day, and has always eaten 5 small meals daily. Martha has to put a lot of time into caring for her mother, so it is almost a “blessing” that Martha is sleeping and eating less. She is worried about her own health though and wants to know why, at her age, she suddenly needs less sleep.
To prepare:
- Review the three scenarios, as well as Chapter 6 in the Huether and McCance text.
- Identify the pathophysiology of the disorders presented in the scenarios, including their associated alterations. Consider the adaptive responses to the alterations.
- Review the “Mind Maps—Dementia, Endocarditis, and Gastro-oesophageal Reflux Disease (GERD)” media in this week’s Learning Resources. Then select one of the disorders you identified from the scenarios. Use the examples in the media as a guide to construct a mind map for the disorder you selected. Consider the epidemiology, pathophysiology, risk factors, clinical presentation, and diagnosis of the disorder, as well as any adaptive responses to alterations.
To complete:
Write a 2- to 3-page paper that addresses the following:
- Explain the pathophysiology of the disorders depicted in the scenarios, including their associated alterations. Be sure to describe the patients’ adaptive responses to the alterations.
- Construct a mind map of your selected disorder. Include the epidemiology, pathophysiology, risk factors, clinical presentation, and diagnosis of the disorder, as well as any adaptive responses to alterations.
Attached is a SAMPLE paper to help guide you. Thanks
SAMPLE mind map link
Zimbron, J. (2008). Mind maps—Dementia, endocarditis, and gastro-oesophageal reflux disease (GERD) [PDF]. Retrieved from http://www.medmaps.co.uk/beta/
Gastro-oesophageal reflux disease. [Image]. Used with permission of MedMaps.
Running Head: Adaptive Response 1
Adaptive Response
Soha Alammoury
Walden University
NURS-6501N-1, Advanced Pathophysiology
March 15, 2015
Running Head: Adaptive Response 2
Adaptive Response
Scenario 1: Tonsillitis
The disorder depicted in the first scenario is tonsillitis. Tonsillitis can be caused by either
a viral or bacterial infection, although viral infections are more common. Bacteria cause 15-30%
of cases of pharyngotonsillitis. Anaerobic bacteria play an important role in tonsillar disease.
Most cases of bacterial tonsillitis are caused by group A beta-hemolytic Streptococcus pyogenes
(GABHS) (Shah & Meyers, 2014).
The adaptive responses associated with tonsillitis include fever, sore throat, foul breath,
dysphagia, odynophagia, swollen, red tonsils, headache, as well as loss of appetite. Tonsillitis
caused by Streptococcus species typically occurs in children aged 5-15 years (Shah & Meyers,
2014). The child in the scenario presents with a fever, tympanic membranes reddened on the
periphery, throat is erythematous with 4+ tonsils and diffuse exudates, and anterior cervical
nodes are tender to touch.
Scenario 2: Allergic Contact Dermatitis
The disorder depicted in the second scenario is allergic contact dermatitis. Allergic
contact dermatitis is “a common form of cell-mediated or delayed hypersensitivity that responds
in an interaction of skin barrier function, reaction to irritants, and neuronal responses, such as
pruritus” (Huether & McCance, 2012). With the pathophysiology of allergic contact dermatitis,
“as the allergens contacts the skin, the allergen is bound to a carrier protein, forming a sensitizing
antigen. The Langerhans cells (dendritic cells) process the antigen and carry it to T cells that then
become sensitized to the antigen, inducing the release of inflammatory cytokines and the
symptoms of dermatitis” (Huether & McCance, 2012). The disease is induced by chemicals and
Running Head: Adaptive Response 3
metal ions which penetrate the skin and form complexes with host proteins (Freudenberg, Esser,
Jakob, Galanos, & Martin, 2009).
The adaptive responses associated with allergic contact dermatitis include fever, itching,
erythema as well as pain. There are many common allergens including: adhesives, fabrics,
clothing, fragrances, nail polish, poison ivy, latex and metal. The individual in the scenario
works with abrasive solvents and chemicals which are most likely the reason for his problem of
redness and irritation in his hands. Allergy testing as well as physical assessment can help in
diagnosing.
Scenario 3: Depression
The disorder depicted in the third scenario is depression. There are many different factors
that cause depression. These factors include trauma, genetics, life circumstances (such as marital
status, finances), and drug and alcohol abuse. “Clinical and preclinical trials suggest a
disturbance in central nervous system serotonin (5-HT) activity as an important factor. The role
of CNS 5-HT activity in the pathophysiology of major depressive disorder is suggested by the
therapeutic efficacy of selective serotonin reuptake inhibitors (SSRIs). In addition, studies have
shown that an acute, transient relapse of depressive symptoms can be produced in research
subjects in remission using tryptophan depletion, which causes a temporary reduction in CNS 5-
HT levels” (Halverson & Bienenfeld, 2015).
The adaptive responses associated with depression include changes in sleep, changes in
appetite, lack of concentration, loss of energy, lack of interest, low self-esteem, hopelessness,
changes in movement and physical aches and pains (“National Alliance on Mental Illness –
Depression,” 2015). In the scenario, Martha’s clinical presentation include a “racing heart,” loss
of appetite, and trouble sleeping.
Running Head: Adaptive Response 4
References
Freudenberg, M., Esser, P., Jakob, P., Galanos, C., & Martin, S. (2009). Innate and adaptive
immune responses in contact dermatitis: analogy with infections. US National Library of
Medicine National Institutes of Health, 144(2), 173-85.. Retrieved from
http://www.ncbi.nlm.nih.gov/pubmed/19357624
Halverson, J., & Bienenfeld, D. (2015). Depression. Retrieved from
http://emedicine.medscape.com/article/286759-overview#aw2aab6b2b3
Huether, S., & McCance, K. (2012).Understanding pathophysiology (5th ed.). St. Louis, MO:
Mosby.
National Alliance on Mental Illness – Depression. (2015). Retrieved from
http://www.nami.org/Learn-More/Mental-Health-Conditions/Depression
Shah, U., & Meyers, A. (2014). Tonsillitis and Peritonsillar Abscess. Retrieved from
http://emedicine.medscape.com/article/871977-overview#aw2aab6b2b2aa
Running Head: Adaptive Response 5




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